Striatal subregional 6‐[18F]fluoro‐L‐dopa uptake in early Parkinson's disease: A two‐year follow‐up study
Identifieur interne : 003175 ( Main/Exploration ); précédent : 003174; suivant : 003176Striatal subregional 6‐[18F]fluoro‐L‐dopa uptake in early Parkinson's disease: A two‐year follow‐up study
Auteurs : Anna Brück [Finlande] ; Sargo Aalto [Finlande] ; Elina Nurmi [Finlande] ; Tero Vahlberg [Finlande] ; Jörgen Bergman [Finlande] ; Juha O. Rinne [Finlande]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
English descriptors
- KwdEn :
- Aged, Corpus Striatum (radionuclide imaging), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dihydroxyphenylalanine (pharmacokinetics), Disease Progression, Dominance, Cerebral (physiology), Female, Fluorine Radioisotopes (diagnostic use), Fluorine Radioisotopes (pharmacokinetics), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (radionuclide imaging), Parkinson's disease, Positron-Emission Tomography, Putamen (radionuclide imaging), Reference Values, [18F]fluorodopa, positron emission tomography, progression.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorine Radioisotopes.
- chemical , pharmacokinetics : Dihydroxyphenylalanine, Fluorine Radioisotopes.
- physiology : Dominance, Cerebral.
- radionuclide imaging : Corpus Striatum, Parkinson Disease, Putamen.
- Aged, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Reference Values.
Abstract
Thirty‐one drug‐naive patients with Parkinson's disease (PD) underwent 6‐[18F]fluoro‐L‐dopa (F‐dopa) positron emission tomography (PET) scan at the time of the diagnosis (baseline) and 2 years later in order to investigate F‐dopa uptake in striatal and extrastriatal regions during the first years of early PD. Twenty‐four healthy controls underwent one F‐dopa PET scan. The regional differences in the striatal and extrastriatal regions were analyzed with statistical parametric mapping and automated region of interest analyses. Our study shows that the F‐dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls. During the first years of PD, there is a progressive regional decline in striatal F‐dopa uptake, the dorsal part of caudal putamen being still the most severely affected region. The absolute decline is equal between the striatal subregions. This suggests that the decline of dopamine function starts from the dorsocaudal putamen, but once started, the rate of progression is equal between the subregions of the striatum. In contrast to the striatal decline, the increased cortical F‐dopa uptake prevails at least during the first years of PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20855
Affiliations:
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Rinne</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Turku PET Center, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName><orgName type="university">Université de Turku</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology, Åbo Akademi University, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="958">958</biblScope><biblScope unit="page" to="963">963</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7BA990E042A5EDC641FBE48FFB088A255C0392E0</idno><idno type="DOI">10.1002/mds.20855</idno><idno type="ArticleID">MDS20855</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Corpus Striatum (radionuclide imaging)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Dihydroxyphenylalanine (pharmacokinetics)</term><term>Disease Progression</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Fluorine Radioisotopes (diagnostic use)</term><term>Fluorine Radioisotopes (pharmacokinetics)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson's disease</term><term>Positron-Emission Tomography</term><term>Putamen (radionuclide imaging)</term><term>Reference Values</term><term>[18F]fluorodopa</term><term>positron emission tomography</term><term>progression</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Fluorine Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Fluorine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Reference Values</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thirty‐one drug‐naive patients with Parkinson's disease (PD) underwent 6‐[18F]fluoro‐L‐dopa (F‐dopa) positron emission tomography (PET) scan at the time of the diagnosis (baseline) and 2 years later in order to investigate F‐dopa uptake in striatal and extrastriatal regions during the first years of early PD. Twenty‐four healthy controls underwent one F‐dopa PET scan. The regional differences in the striatal and extrastriatal regions were analyzed with statistical parametric mapping and automated region of interest analyses. Our study shows that the F‐dopa uptake in unmedicated early PD is most severely decreased in the dorsal part of caudal putamen but significant decrease can be seen throughout the striatum compared with controls. During the first years of PD, there is a progressive regional decline in striatal F‐dopa uptake, the dorsal part of caudal putamen being still the most severely affected region. The absolute decline is equal between the striatal subregions. This suggests that the decline of dopamine function starts from the dorsocaudal putamen, but once started, the rate of progression is equal between the subregions of the striatum. In contrast to the striatal decline, the increased cortical F‐dopa uptake prevails at least during the first years of PD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name></region><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name><name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name><name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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